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Benzyl alcohol is a popular aromatic alcohol found in a variety of household products such as soaps, topical creams, lotions, and facial cleansers

GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

Once inside the RBC, free riboflavin is sequentially metabolised by flavokinase and FAD synthetase to generate FMN and FAD

-Glutamylcysteine synthetase was reported to be the rate-limiting step for the overall glutathione biosynthesis process 1,29

Hence, to assess whether SYNCRIP depletion enhances susceptibility to ferroptosis directly, we measured malondialdehyde (MDA) levels, a key marker of lipid peroxidation

This H-bonding network in canonical PDOs prevents the active-site water molecule from participating in the oxidation of the persulfide product, leading only to the formation of an RSSO 2 - intermediate, which is then hydrolyzed by an external water molecule to release sulfite 40